Em paralelo às atividades de assistência, o Dr. Luciano Furlanetti atua há aproximadamente 20 anos em pesquisa clínica e experimental, tendo trabalhado em grupos de pesquisa na Universidade de São Paulo (USP) durante a graduação e residência médica, e posteriormente nas Universidades de Freiburg e Saarland, na Alemanha, e no King’s College London.
O Dr Luciano concluiu o doutorado em medicina com a nota suma cum laude, na Universidade de Freiburg (2015), tendo sido reconhecido Doutor em Neurologia, pela Universidade de São Paulo (USP) no ano seguinte. Atualmente, atua ativamente em ensino e pesquisa, como professor associado visitante do IoPPN, no King’s College de Londres.
Linhas de Pesquisa
As linhas de pesquisa abrangem, entre outros tópicos:
Transplante de células tronco mesencefálicas no tratamento da doença de Parkinson:
FURLANETTI, L. L. ; CORDEIRO, J. G. ; CORDEIRO K. K.; GARCIA, J. ; WINKLER, C. ; LEPSKI, G. A. ; COENEN V. A. ; NIKKHAH G. ; DÖBRÖSSY M. D. 2015. High frequency stimulation of the Subthalamic Nucleus improves graft survival and behavioural outcome in a rat model of Parkinson’s disease. Neurorehabil Neural Repair. 2015 Nov-Dec;29(10):1001-12. doi: 10.1177/1545968315581419. Epub Apr 9. PMID: 25857428
CORDEIRO, K. K.; CORDEIRO, J. G. ; FURLANETTI, L. L. ; GARCIA, J. ; TENÓRIO, S. B. BERNARDO ; WINKLER, C. ; DÖBRÖSSY, M. D. ; NIKKHAH, G. 2014. Subthalamic nucleus lesion improves cell survival and functional recovery following dopaminergic cell transplantation in parkinsonian rats. Eur J Neurosci. 2014 May;39(9):1474-84. doi: 10.1111/ejn.12541. Epub Mar 14. PMID: 24628951
LOPEZ, WO. ; FURLANETTI, L. L. ; NIKKHAH, G. ; SCHUELTKE, E. ; TRIPPEL, M. 2014. Stereotactic planning software for human neurotransplantation: Suitability in 22 surgical cases of Huntington’s disease.Restor Neurol Neurosci. ;32(2):259-68. doi: 10.3233/RNN-130340. PMID: 24164802
WINKLER, CHRISTIAN ; REIS, JANINE ; HOFFMANN, NADIN ; GELLNER, ANNE-KATHRIN ; MÜNKEL, CHRISTIAN ; CURADO, MARCO ROCHA ; FURLANETTI, LUCIANO ; GARCIA, JOANNA ; DÖBRÖSSY, MÁTÉ D. ; FRITSCH, BRITA. 2017. Anodal Transcranial Direct Current Stimulation Enhances Survival and Integration of Dopaminergic Cell Transplants in a Rat Parkinson Model. Eneuro, v. 4, p. ENEURO.0063-17.
Estimulação cerebral profunda em doença de Parkinson, distúrbios do movimento e estereotaxia adulto e pediátrico
FURLANETTI L, BAIG A, RASLAN A, VELICU MA, BURFORD C, AKHBARI M, GERMAN E, SAHA R, SAMUEL M, ASHKAN K. Factors influencing driving following DBS surgery in Parkinson’s disease: A Single UK experience and review of the literature. J Clin Med 2022. doi: 10.3390/jcm12010166
FURLANETTI et al. 2020. O-arm stereotactic imaging in deep brain stimulation surgery workflow: A utility and cost-effectiveness analysis. Stereotact Funct Neurosurg doi:10.1159/000510344
FURLANETTI L et al 2020. Fixed-Life or Rechargeable Battery for Deep Brain Stimulation: A Prospective Long-Term Study of Patient’s Preferences. Stereotactic and Functional Neurosurgery. PMID: 32069466 doi: 10.1159/000505700.
ASHKAN K, VELICU MA, FURLANETTI L. Deep brain stimulation-induced neuroprotection: A critical appraisal. Eur J Paediatr Neurol 2022. doi: 10.1016/j.ejpn.2022.02.001
MELO M, FURLANETTI L, HASEGAWA, MUNDIL, ASHKAN K. et al 2020. Comparison of direct MRI guided versus atlas-based targeting for subthalamic nucleus and globus pallidus deep brain stimulation. British Journal of Neurosurgery Jan/2021. DOI: 10.1080/02688697.2020.1850641
ESPINOZA MARTINEZ JA, ARANGO GJ, FONOFF ET, REITHMEIER T, ESCOBAR OA, FURLANETTI L, ALVAREZ BERASTEGUI GR, FERNANDES DA SILVA FE, CONTRERAS LOPEZ WO. 2015. Deep brain stimulation of the globus pallidus internus or ventralis intermedius nucleus of thalamus for Holmes tremor. Neurosurg Rev. 2015 Oct;38(4):753-63. doi: 10.1007/s10143-015-0636-0. Epub May 20. PMID: 25990341
Tratamento neurocirúrgico da distonia
FURLANETTI L et al. 2021. Targeting accuracy of robot-assisted deep brain stimulation surgery in childhood-onset dystonia: a single-center prospective cohort analysis of 45 consecutive cases (accepted in Journal of Neurosurgery: Pediatrics)
TAMBIRAJOO & FURLANETTI L et al 2020. Deep brain stimulation of the internal pallidum in Lesch-Nyhan Syndrome: clinical outcomes and connectivity analysis. Neuromodulation, DOI: 10.1111/ner.13217
TAMBIRAJOO, FURLANETTI L, SAMUEL M, ASHKAN, K et al 2020. Subthalamic Nucleus Stimulation in Post-Infarct dystonia. Stereotactic and Functional Neurosurgery. DOI: 10.1159/000509317
MARTÍNEZ, J. E. ; PINSKER, M. O. ; ARANGO, G. J. ; GARCIA, X. ; OSCAR, A. ; FURLANETTI, L. L. ; REITHMEIER, T. ; ARANDA, I. ; MARIN, J. H. ; LOPEZ, W.O. 2014. Neurosurgical treatment for dystonia: Long-term outcome in a case series of 80 patients. Clin Neurol Neurosurg. Aug;123:191-8. doi: 10.1016/j.clineuro.2014.05.012. Epub 2014 May 29. PMID: 24995965
Estimulação cerebral profunda no tratamento da depressão refratária e transtornos psiquiátricos
ASHKAN K, MIRZA A, TAMBIRAJOO K, FURLANETTI L. 2020. Deep brain stimulation in the management of paediatric neuropsychiatric conditions: Current evidence and future directions. European Journal of Paediatric Neurology. doi.org/10.1016/j.ejpn.2020.09.004
FURLANETTI, L. L., COENEN, V. A., DÖBRÖSSY, M. D. 2015. Ventral tegmental area dopaminergic lesion-induced depressive phenotype in the rat is reversed by deep brain stimulation of the medial forebrain bundle. Behav Brain Res. 2016 Feb 15;299:132-40. doi: 10.1016/j.bbr.2015.11.036. Epub Dec 2. PMID: 26657994
FURLANETTI, L. L., COENEN, V. A., ARANDA, I. A., DÖBRÖSSY, M. D. 2015. Chronic deep brain stimulation of the medial forebrain bundle reverses depressive-like behavior in a hemiparkinsonian rodent model. Exp Brain Res. 2015 Nov;233(11):3073-85. doi: 10.1007/s00221-015-4375-9. Epub Jul 21. PMID: 26195164
DOBROSSY, M. D. ; FURLANETTI, L. L. ; COENEN, V. A. 2015. Electrical stimulation of the medial forebrain bundle in pre-clinical studies of psychiatric disorders. Neurosci Biobehav Rev. Feb;49:32-42. doi: 10.1016/j.neubiorev.2014.11.018. Epub 2014 Dec 9. Review. PMID: 25498857
FURLANETTI, L. L., DÖBRÖSSY, M. D., ARANDA, I. A., COENEN, V. A. 2015. Feasibility and Safety of Continuous and Chronic Bilateral Deep Brain Stimulation of the Medial Forebrain Bundle in the Naïve Sprague-Dawley Rat. Behav Neurol. 2015;2015:256196. doi: 10.1155/2015/256196. Epub Apr 15. PMID: 25960609
THIELE S, SPEHL TS, FRINGS L, BRAUN F, FERCH M, REZVANI AH, FURLANETTI LL, MEYER PT, COENEN VA, DÖBRÖSSY MD. 2016. Long-term characterization of the Flinders Sensitive Line rodent model of human depression: Behavioral and PET evidence of a dysfunctional entorhinal cortex. Behav Brain Res. Mar 1;300:11-24. doi: 10.1016/j.bbr.2015.11.026. Epub 2015 Nov 30. PMID: 26658515
THIELE S, FURLANETTI L, PFEIFFER LM, COENEN V, DÖBRÖSSY M. 2018. The effects of bilateral, continuous, and chronic Deep Brain Stimulation of the medial forebrain bundle in a rodent model of depression. EXPERIMENTAL NEUROLOGY, v. 303, p. 153-161.
DBS e Estimulação de nervo vago no tratamento da epilepsia refratária em crianças e adultos
TERRA, V. C. ; FURLANETTI, L. L. ; NUNES, A. ; THOMÉ, U. ; NISYIAMA, M. ; SAKAMOTO, A. C. ; MACHADO, H. R. 2013. Vagus nerve stimulation in pediatric patients: Is it really worthwhile? Epilepsy Behav. 2014 Feb;31:329-33. doi: 10.1016/j.yebeh.2013.10.011. Epub Nov 5. PMID: 24210463
BENEDETTI-ISAAC JC, TORRES-ZAMBRANO M, VARGAS-TOSCANO A, PEREA-CASTRO E, ALCALÁ-CERRA G, FURLANETTI LL, REITHMEIER T, TIERNEY TS, ANASTASOPOULOS C, FONOFF ET, CONTRERAS LOPEZ WO. 2015. Seizure frequency reduction after posteromedial hypothalamus deep brain stimulation in drug-resistant epilepsy associated with intractable aggressive behavior. Epilepsia. Jul;56(7):1152-61. doi: 10.1111/epi.13025. Epub 2015 Jul 4. PMID: 26146753
Tratamento neurocirúrgico da hidrocefalia em pacientes adultos e pediátricos
FURLANETTI L et al 2020. Shunt Technology in Pediatric Neurosurgery: Current options and Scientific Evidence. Archives of Pediatric Neurosurgery.
FURLANETTI L. L. ; SANTOS, M. V. ; OLIVEIRA, R. S. 2012. The Success of Endoscopic Third Ventriculostomy in Children: Analysis of Prognostic Factors. Pediatr Neurosurg. 48(6):352-9. doi: 10.1159/000353619. Epub 2013 Jul 31. PMID: 23920441
FURLANETTI L. L. ; SANTOS, M. V. ; OLIVEIRA, R. S. 2013. Neuroendoscopic surgery in children: an analysis of 200 consecutive procedures. Arq Neuropsiquiatr. Mar;71(3):165-70. PMID: 23563716
Neurooncologia e Neurocirurgia Oncológica
LAVRADOR, FURLANETTI L, ASHKAN K et al 2020. Brain mapping for lesions in primary motor cortex: integrated surgical approach. Neuro-Oncology. https://doi.org/10.1093/neuonc/noz167.078
DE OLIVEIRA RS, DERIGGI DJ, FURLANETTI LL, SANTOS MV, VALERA ET, BRASSESCO MS, MACHADO HR. 2014. The impact of surgical resection of giant supratentorial brain tumor in pediatric patients: safety and neurological outcome evaluated in 23 consecutive cases. Childs Nerv Syst. 2015 Jan;31(1):67-75. doi: 10.1007/s00381-014-2583-4. Epub Nov 6. PMID: 25374270
FURLANETTI, L. L. ; MONACO, B. A. ; CORDEIRO, J. G. ; LOPEZ, WO. ; TRIPPEL, M. 2014. Frame-based stereotactic neurosurgery in children under the age of seven: Freiburg University s Experience from 99 consecutive cases. Clin Neurol Neurosurg. 2015 Mar;130:42-7. doi: 10.1016/j.clineuro.2014.12.011. Epub Dec 30.
SANTOS, M. V.; FURLANETTI, L. L.; BEZERRA J., DUARTE M.; OLIVEIRA, R. S. 2013. Epidermoid cyst mimicking an intrinsic brainstem tumor. Neurocirugia (Astur). May-Jun;24(3):135-8. doi: 10.1016/j.neucir.2012.09.007. Epub 2012 Dec 8. PMID: 23228590
SANTOS, M. V.; FURLANETTI, L. L.; BRASSESCO, M. S.; VALERA, E. T.; TONE, L. G.; OLIVEIRA R. S. 2012. Pediatric meningioma: A single-center experience with 15 consecutive cases and review of the literature. Childs Nerv Syst. 2012 Nov;28(11):1887-96. doi: 10.1007/s00381-012-1823-8. Epub Jun 6. Review. PMID: 22669518
FURLANETTI, L. L. ; SANTOS, M. V.; BRASSESCO, M. S. ; VALERA, E. T. ; OLIVEIRA RS. 2012. Metachronous occurrence of non-radiation-induced brain cavernous hemangioma and medulloblastoma in a child with neurofibromatosis type I phenotype. J Pediatr Neurosci. Jan;7(1):43-6. doi: 10.4103/1817-1745.97623. PMID: 22837778
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